The Science and Technology Park of the University of Porto, UPTEC, is an outstanding example of how to bring academic knowledge and business closer together, through its strategy of sharing research findings and fostering local entrepreneurship. It is helping to turn the northern region of Portugal into a centre for innovation. Co-financed by the European Regional Development Fund, the project is spreading modern, structural change across the north of Portugal, demonstrating how active universities in previously poorer regions of Europe can lead the move to smart growth.